Figure 1
From: Intramyocardial hemorrhage contributes to microvascular obstruction in acute myocardial infarction
1st and 2nd row: Pig hearts treated with an intracoronary injection of collagenase beyond the second diagonal branch of the LAD (inset in 600 mcg image) after a brief ischemic episode of 8 min. For a dose of >800 mcg, collagenase resulted in hemorrhage (reddish areas) as is apparent on the explanted hearts; amount of hemorrhage increased with dose. 3rd row: Hematoxylin and eosin stains from the right and left ventricle (RV, LV) demonstrated widespread areas of red blood cells dispersed throughout the myocardium.