- Poster presentation
- Open access
- Published:
Pulmonary pulse wave velocity as assessed with velocity-encoded MRI
Journal of Cardiovascular Magnetic Resonance volume 14, Article number: P280 (2012)
Summary
Pulmonary pulse wave velocity has proven to be an excellent indicator of pulmonary vascular wall stiffness. In this study a novel MRI method was evaluated, showing rapid assessment of pulmonary pulse wave velocity with excellent repeatability and observer reproducibility.
Background
Pulmonary pulse wave velocity has proven to be an excellent indicator of pulmonary vascular wall stiffness. The main objective of this study was to evaluate a novel magnetic resonance imaging (MRI) method to rapidly assess pulmonary pulse wave velocity (PWV) and to test repeatability and observer reproducibility of the proposed technique.
Methods
In 15 healthy volunteers (7 male; mean±SD age 19±6 years) pulmonary PWV was prospectively assessed between the proximal main pulmonary artery (MPA) and just before the first branching of the distal left pulmonary artery (LPA). One-directional through-plane velocity-encoded (VE) MRI using breath holds was used to assess the pulmonary flow at the levels of MPA and distal LPA with a temporal resolution of 15 ms. Pulmonary PWV was calculated by dividing the pulmonary path length between the measurement sites by the transit time between the arrival of the systolic wave front at these sites. The volunteers were studied twice to test reproducibility in PWV-assessment.
Results
Results are expressed as mean±SD, Pearson correlation coefficient (PCC) and intraclass correlation (ICC). Acquisition time of the MRI examination was 2±1 minutes and image analysis lasted for 2±1 minutes. Both observers showed good agreement for pulmonary distance (observer 1: 52.2±11.0 mm vs. observer 2: 52.7±11.1 mm; PCC=0.99) and pulmonary PWV (observer 1: PWV 2.73±1.05 m/s vs. observer 2: 2.76±1.06 m/s; PCC=0.99). Reproducibility of pulmonary PWV was high for both observers (observer 1: 2.73±1.05 m/s vs. 2.72±1.04 m/s, ICC=1.00, p<0.01; observer 2: 2.76±1.06 m/s vs. 2.75±1.06 m/s, ICC=1.00, p<0.01; ICC observer 1 vs. observer 2: 0.99, p<0.01).
Conclusions
Rapid non-invasive VE MRI assessment of pulmonary pulse wave velocity shows low interobserver and intraobserver variability and can be determined with high reproducibility.
Funding
No disclosures.
Author information
Authors and Affiliations
Rights and permissions
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
About this article
Cite this article
Grotenhuis, H., Stomp, W., Westenberg, J.J. et al. Pulmonary pulse wave velocity as assessed with velocity-encoded MRI. J Cardiovasc Magn Reson 14 (Suppl 1), P280 (2012). https://doi.org/10.1186/1532-429X-14-S1-P280
Published:
DOI: https://doi.org/10.1186/1532-429X-14-S1-P280