Evaluation of diastolic function in left ventricular (LV) volume versus time curve. A) LV filling pattern in a normal subject. Early peak filling rate (PFR) is derived from the steepest gradient in the volume curve in the early filling phase. The horizontal white line demonstrates the diastolic diastasis phase (plateau) separating the early and late diastole. B) LV filling pattern in a metabolic syndrome patient with LV diastolic dysfunction demonstrating a depression of diastolic plateau and early PFR (arrow).