| |
All patients
|
High EPA group
|
Low EPA group
|
*P value
|
|---|
| |
(n = 127)
|
(n = 64)
|
(n = 63)
| |
|---|
|
Age
|
71.6 ± 7.8
|
71.8 ± 7.6
|
70.1 ± 9.1
|
0.18
|
|
Male
|
116 (91%)
|
60 (94%)
|
56 (89%)
|
0.12
|
|
Height, cm
|
163.4 ± 7.1
|
162.9 ± 7.7
|
164.4 ± 6.5
|
0.29
|
|
Body weight, kg
|
65.4 ± 11.1
|
65.9 ± 11.7
|
64.3 ± 9.7
|
0.51
|
|
Body mass index, kg/m2
|
24.3 ± 3.0
|
24.6 ± 3.2
|
23.7 ± 2.5
|
0.69
|
|
Systolic BP, mmHg
|
137.9 ± 20.8
|
135.7 ± 19.2
|
140.5 ± 22.3
|
0.24
|
|
Diastolic BP, mmHg
|
70.7 ± 12.6
|
69.6 ± 13.3
|
71.8 ± 11.9
|
0.35
|
|
Heart rate, beats per minute
|
67.9 ± 12.4
|
66.3 ± 10.7
|
69.6 ± 13.8
|
0.18
|
|
Cardiovascular history
| | | | |
|
Myocardial infarction
|
42 (33%)
|
19 (30%)
|
23 (37%)
|
0.64
|
|
Angina pectoris
|
64 (50%)
|
35 (55%)
|
29 (46%)
|
0.22
|
|
Coronary risk factors
| | | | |
|
Hypertension
|
93 (73%)
|
47 (73%)
|
46 (73%)
|
0.88
|
|
Dyslipidemia
|
92 (72%)
|
46 (72%)
|
46 (73%)
|
0.84
|
|
Diabetes Mellitus
|
39 (31%)
|
20 (31%)
|
19 (30%)
|
0.89
|
|
Current smoking
|
16 (13%)
|
9 (14%)
|
7 (11%)
|
0.48
|
|
Family history of CAD
|
6 (5%)
|
3 (5%)
|
3 (5%)
|
0.92
|
|
Obesity
|
41 (32%)
|
25 (39%)
|
16 (25%)
|
0.13
|
|
Blood test results
| | | | |
|
EPA, μg/mL
|
85.3 ± 53.9
|
121.5 ± 53.3
|
48.4 ± 16.9
|
<0.001
|
|
DHA, μg/mL
|
139.1 ± 54.4
|
163.2 ± 51.9
|
109.0 ± 35.2
|
<0.001
|
|
AA, μg/mL
|
178.6 ± 52.9
|
171.0 ± 47.3
|
179.6 ± 52.5
|
0.34
|
|
Total cholesterol, mmol/L
|
179.0 ± 38.6
|
183.1 ± 36.7
|
172.8 ± 37.9
|
0.12
|
|
LDL cholesterol, mmol/L
|
101.9 ± 26.7
|
106.6 ± 31.7
|
100.2 ± 27.5
|
0.23
|
|
HDL cholesterol, mmol/L
|
57.3 ± 15.9
|
66.1 ± 64.0
|
53.0 ± 14.3
|
0.12
|
|
Triglyceride, mmol/L
|
179.0 ± 38.6
|
171.1 ± 125.1
|
157.6 ± 105.6
|
0.51
|
|
Hemoglobin, g/dL
|
14.3 ± 1.6
|
14.3 ± 1.4
|
14.1 ± 1.6
|
0.58
|
|
HbA1c, %
|
6.0 ± 0.9
|
6.0 ± 1.0
|
5.8 ± 0.8
|
0.21
|
|
eGFR, mL/min/1.73 m2
|
65.7 ± 14.0
|
64.5 ± 13.2
|
65.6 ± 13.6
|
0.65
|
|
CRP, mg/dL
|
0.30 ± 1.0
|
0.15 ± 0.21
|
0.42 ± 1.37
|
0.25
|
|
BNP, pg/dl
|
53.3 ± 65.0
|
46.6 ± 43.9
|
45.9 ± 63.2
|
0.94
|
|
Medication use
| | | | |
|
Statin
|
82 (65%)
|
41 (64%)
|
41 (65%)
|
0.86
|
|
Antiplatelet agent
|
108 (85%)
|
52 (81%)
|
56 (89%)
|
0.91
|
|
Calcium channel blocker
|
45 (35%)
|
22 (34%)
|
23 (37%)
|
0.99
|
|
β blocker
|
48 (38%)
|
21 (33%)
|
27 (43%)
|
0.26
|
|
ACE/ARB
|
73 (57%)
|
33 (52%)
|
40 (63%)
|
0.17
|
- Values are presented as mean ± standard deviation (SD).
- * P value represents significance of difference between low EPA group and high EPA group.
- EPA, eicosapentaenoic acid; AA, arachidonic acid, DHA, docosahexaenoic acid; BP, blood pressure; CAD, coronary artery disease; LDL; low density lipoprotein; HDL, high density lipoprotein, eGFR, estimated glomerular filtration rate; CRP, C-reactive protein; BNP, brain natriuretic peptide; ACE, angiotensin converting enzyme inhibitor; ARB angiotensin receptor blocker.
