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Table 4 Predictors of coronary flow reserve >2.5 determined by univariate and multivariate analyses

From: Relationship between coronary flow reserve evaluated by phase-contrast cine cardiovascular magnetic resonance and serum eicosapentaenoic acid

  Univariate analysis Multivariate analysis
Odds ratio 95% CI P value Odds ratio 95% CI P value
Patients’ characteristics       
  Age, per year 1.01 0.97 – 1.05 0.65 Not selected   
  Male, men 1.58 0.43 – 5.68 0.49 Not selected   
  Systolic blood pressure, per mmHg 0.99 0.97 – 1.01 0.99 Not selected   
  Diastolic blood pressure, per mmHg 0.98 0.95 – 1.02 0.31 Not selected   
  Heart rate. Per bpm 0.98 0.95 – 1.01 0.19 Not selected   
  History of myocardial infarction , yes 1.27 0.57 – 2.86 0.55 Not selected   
  History of angina pectoris, yes 1.56 0.71 – 3.56 0.26 Not selected   
Coronary risk factors       
  Hypertension, yes 0.69 0.26 – 0.69 0.45 Not selected   
  Dyslipidemia, yes 0.67 0.25 – 1.77 0.42 Not selected   
  Diabetes Mellitus, yes 0.35 0.16 – 0.77 0.009 0.39 0.17 - 0.89 0.026
  Current smoking, yes 1.49 0.50 – 4.45 0.48 Not selected   
  Family history of CAD, yes 1.21 0.23 – 6.40 0.82 Not selected   
  Obesity, BMI ≥ 25 kg/m2, yes 1.41 0.66 – 3.00 0.37 Not selected   
Blood testing       
  EPA, per μg/mL 1.01 1.00 – 1.02 0.017 1.01 1.00 – 1.02 0.008
  Total cholesterol, per mmol/L 1.00 0.99 – 1.01 0.62 Not selected   
  LDL cholesterol, per mmol/L 1.00 0.99 – 1.01 0.93 Not selected   
  HDL cholesterol, per mmol/L 1.02 0.99 – 1.04 0.21 Not selected   
  Triglyceride, per mmol/L 1.00 0.99 – 1.00 0.97 Not selected   
  HbA1c, per% 0.92 0.63 – 1.34 0.68 Not selected   
  eGFR, per mL/min/1.73 m2 0.99 0.97 – 1.03 0.94 Not selected   
  CRP, per mg/dL 0.57 0.18 – 1.80 0.34 Not selected   
  BNP, per pg/dl 1.00 0.99 – 1.01 0.66 Not selected   
Cine CMR       
  LVEDVI, per mL/m2 1.00 0.99 – 1.01 0.75 Not selected   
  LVESVI, per mL/m2 0.99 0.98 – 1.01 0.32 Not selected   
  LVEF, per% 1.03 1.00 – 1.06 0.066 Not selected   
  LVMI, per g/m2 0.97 0.95 – 1.00 0.019 0.97 0.95-0.99 0.024
Late Gadolinium enhanced CMR       
  Presence of LGE, yes 0.65 0.32 – 1.32 0.24 Not selected   
  LGE (%), per% 0.97 0.95 – 1.02 0.35 Not selected   
  1. The variables with p value < 0.05 in the univariate analysis were included in the multivariate analysis.
  2. CI, confidence interval; CFR, coronary flow reserve; LGE, late gadolinium enhancement; BMI, body mass index; EPA, eicosapentaenoic acid; LDL; low density lipoprotein; HDL, high density lipoprotein, eGFR, estimated glomerular filtration rate; CRP, C-reactive protein; BNP, brain natriuretic peptide; CMR, cardiovascular magnetic resonance; LV, left ventricle; EDVI, end-diastolic volume index; ESVI, end-systolic volume index; SVI, stroke volume index; EF, ejection fraction; LVMI, left ventricular mass index.