Figure 4
Left ventricular strain is reduced in the subepicardium (A) with relative preservation of function in the subendocardium (B) in obese mice fed a high-fat diet (HFD) compared to mice on a low-fat diet (LFD). Note that radial strain is positive because the heart thickens (lengthens) in this direction during systolic contraction while circumferential (circumf) and longitudinal (longitud) strains are negative because the heart shortens in these directions during systole. Bars show mean ± standard deviation.