Figure 5

Obesity has a differential effect on the strains in the myocardial layers of the left ventricle. The cardiac wall can be subdivided into three layers (Endo = subendocardium, Mid = mid-myocardium, Epi = subepicardium) which are known to have different peak strains in normal mice. Left ventricular circumferential (circumf), radial, and longitudinal (longitud) strains are reduced in the subepicardium with relative preservation of function in the subendocardium in obese mice fed a high-fat diet (HFD). As an example, the purple bar for the reduction in subepicardial strain in the circumferential direction is equal to the difference in height of the green minus the blue bar in Figure 4A, expressed as a percentage of the blue bar.