Examples of CMR scans from newly presenting patients with C282Y homozygous hemochromatosis and heart failure. a) 54 year-old male with presenting myocardial T2* of 5.4 ms and LVEF of 36%. When rescanned 31 months later after venesection, the cardiac T2* had improved to 15.7 ms, and the LVEF to 65%. b) 59 year-old female with presenting cardiac T2* of 7.4 ms and LVEF of 35%. Rescanning 19 months later after venesection showed improvement in T2* to 23.6 ms and LVEF to 61%. In both cases, venesection resulted in considerable improvement in iron loading and cardiac function. Top row: horizontal long axis, middle row: mid-ventricular short axis, bottom row: vertical long axis.