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Table 1 Model input parameters

From: Cost-effectiveness of cardiovascular magnetic resonance and single-photon emission computed tomography for diagnosis of coronary artery disease in Germany

Parameter Value Range Ref.
SnC Sensitivity of CMR 0.82 0.77-0.86 [17]
SpC Specificity of CMR 0.86 0.82-0.89 [17]
SnS Sensitivity of SPECT 0.67 0.60-0.72 [17]
SpS Specificity of SPECT 0.83 0.79-0.86 [17]
SnA Sensitivity of angiography 1.00 N/A [1921]
SpA Specificity of angiography 1.00 N/A [1921]
RC Complication rate with CMR 0.0005 0.0001-0.001 [23]
RS Complication rate with SPECT 0.0005 0.0001-0.001 [20]
RA Complication rate with angiography 0.005 0.001-0.01 [28]
RF Complication rate for patients with CAD and false-negative test results* 0.25 0.15-0.30 [20, 21]
MC Mortality rate due to CMR 0.00005 0.00001-0.0001 [20, 24]
MS Mortality rate due to SPECT 0.00005 0.00001-0.0001 [20, 24]
MA Mortality rate due to angiography 0.00075 0.0001-0.0015 [28]
MF Mortality rate for patients with CAD and false-negative test results* 0.20 0.15-0.25 [19, 20]
NDxC Rate of non-diagnostic CMR 0.05 0.01-0.1 [17, 25]
NDxS Rate of non-diagnostic SPECT 0.05 0.01-0.1 [17, 25]
NDxA Rate of non-diagnostic angiography 0.00 N/A [1921]
CC Cost of CMR [in €] 703 527-879 [31, 34]
CS Cost of SPECT [in €] 504 378-630 [30, 33]
CA Cost of angiography [in €] 2,926 2,195-3,658 [29, 35]
C Cost of a complication# [in €] 14,478 10,859-18,098 [21, 36]
NC No. of patients having CMR 1.0 N/A [21]
NS No. of patients having SPECT 1.0 N/A [21]
NA No. of patients having angiography varies Equation 1a [1921]
NFC No. of false-negative CMR varies Equation 1a [1921]
NFS No. of false-negative SPECT varies Equation 1a [1921]
P Prevalence of CAD varies 0.1-1.0 [1921]
ΔQALY’ QALY extended by CAD therapy* 3.0 2.0-4.0 [20]
ΔQALY Net QALY gained varies Equations 1c,2c [20]
  1. *Over a 10-year follow-up period.
  2. #Assumed to be myocardial infarction (or cerebral, for invasive angiography).
  3. Angiography refers to invasive coronary angiography. Details of the parameters are given in the text.
  4. CAD: coronary artery disease; CMR: cardiovascular magnetic resonance; N/A: not applicable; QALY: quality-adjusted life-year; SPECT: single-photon emission computed tomography.