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Table 1 Baseline values for LVEF, myocardial T2*, LIC, ferritin and 6 minute walk

From: Treatment of heart failure in adults with thalassemia major: response in patients randomised to deferoxamine with or without deferiprone

Patient

Arm

Age

LVEF

T2*

LIC#

Ferritin

6 minute

  

Sex

%

ms

mg/g/dw

μg/L

Walk

   

Base

Base

Base

Base

Distance m

1a

Comb

23, M

51.9

5.1

34.8

5893

526

2a

Comb

30, F

49.9

5.9

4.7

2817

425

3a

Comb

22, M

35.5

2.7

6.7

2961

nd

4a

Comb

30, F

48.9

6.3

12.1

3637

nd

5a

Comb

19, M

38.8

7.1

14.2

3054

nd

6a

Comb

21, M

56.0

21.1

32.1

7125

445

7a

Comb

28, M

55.3

12.3

5.3

1608

550

8a

Comb

33, M

55.2

14.8

9.4

nd

567

9a

Comb

34, M

53.0

10.0

2.9

1962

492

10a

Comb

23, M

53.8

3.3

9.7

2800

389

11a

Comb

28, F

55.4

3.9

7.4

735

359

Mean

 

26.40

51.8

8.4

12.7

3259.2

469.1

SD

  

5.2

5.7

10.8

1924.8

76.5

1b

Mono

19, F

53.9

12.0

11.7

2623.0

nd

2b

Mono

32, F

42.2

10.7

6.2

864.0

689

3b

Mono

32, M

44.8

2.4

32.1

7394.0

nd

4b

Mono

23, M

51.4

9.0

12.4

4649.0

600

5b

Mono

37, M

46.7

8.3

2.7

2329.0

540

6b

Mono

33, M

54.0

5.9

1.5

280.0

644

7b

Mono

19,F

53.1

3.1

2.7

176.0

390

8b

Mono

17, F

47.7

4.1

6.6

1220.0

287

9b

Mono

20.F

54.9

5.7

12.4

nd

nd

mean

 

25.80

49.9

6.8

9.8

2441.9

525.0

SD

  

4.6

3.4

9.4

2485.1

156.1

p comb

 

0.52

0.86

0.49

0.54

0.22

0.39

vs mono

 
  1. Abbreviations: Comb (combination) = DFP + DFO. Mono (monotherapy) = DFO alone. SD = standard deviation of the mean.
  2. # All liver iron measurements were by ferriscan except: arm A patient 5 and 6 arm B patient 4 where SQUID and ARM B patient 3 where liver biopsy was performed.