Table 2 Last visit # values for LVEF, myocardial T2*, LIC ferritin and 6 minute walk
Patient | Arm | DFO | DFO | LVEF | T2* | LIC | Ferritin | 6 minute |
|---|---|---|---|---|---|---|---|---|
Route | Dose | % | ms | mg/g dw | μg/L | Walk | ||
hr/d | mg/kg/d | Final | Final | Final | Final | Distance m | ||
1a | Comb | SC,12 | 52 | 56.0 | 5.7 | 27.7 | 3628 | 492 |
2a | Comb | SC,10 | 51 | 56.6 | 6.3 | nd | 2747 | 554 |
3a | Comb | IV, 24 | 59 | 39.2 | 3.1 | 4.0 | 1154 | 378 |
4a | Comb | SC,12 | 53 | 51.3 | 9.2 | 2.8 | 1811 | 516 |
5a | Comb | IV, 8 | 51 | 58.0 | 6.0 | 6.8 | 3008 | 352 |
6a | Comb | SC,12 | 50 | 61.1 | 20.8 | 16.1 | 4727 | 352 |
7a | Comb | IV, 12 | 46 | 59.6 | 19.2 | 2.9 | 343 | 550 |
8a | Comb | SC,13 | 40 | nd | nd | nd | nd | na |
9a | Comb | SC,14 | 44 | 61.6 | 20.8 | 2.1 | 622 | 475 |
10a | Comb | SC,12 | 50 | 54.6 | 3.9 | 7.7 | 1130 | 397 |
11a | Comb | SC,12 | 50 | 65.4 | 3.5 | 1.7 | 200 | 364 |
mean | 12.9 | 49.6 | 56.3 | 9.8 | 8.0 | 1937.0 | 443 | |
SD | 5.0 | 7.2 | 7.4 | 8.7 | 1528.0 | 82.8 | ||
1b | Mono | SC, 10 | 49 | 50.9 | 11.3 | 14.6 | 4409 | 689 |
2b | Mono | SC,12 | 60 | nd | nd | nd | 439 | na |
3b | Mono | IV, 24 | 50 | nd | nd | nd | v high | na |
4b | Mono | IV, 24 | 41 | 53.3 | 9.4 | 13.8 | 2540 | 590 |
5b | Mono | SC,14 | 30 | 51.6 | 12.8 | 1.3 | 890 | 563 |
6b | Mono | SC,14 | 23 | 66.9 | 9.9 | 2.1 | 413 | 578 |
7b | Mono | SC,12 | 8 | 49.6 | 3.3 | 3.3 | 152 | 410 |
8b | Mono | SC,12 | 50 | 58.2 | 4.0 | 2.3 | 2360 | 398 |
9b | Mono | SC,12 | 50 | nd | nd | ns | ns | ns |
mean | 14.9 | 40.1 | 55.1 | 8.4 | 6.2 | 1600.4 | 538 | |
SD | 16.6 | 6.5 | 3.9 | 6.2 | 1565.7 | 112.9 |