Figure 2

Effects of Ageing on Manganese Contrast Enhancement. Manganese contrast enhancement in older mice (A) and young mice (B). The kinetics of manganese contrast enhancement are slower in the older mice compared to younger mice (P<0.05 repeated measures ANOVA). C. Mid point contrast enhancement in older and younger mice. There was a borderline increase in contrast enhancement in the older Sgcd−/− mice (^#P=0.07 versus WT) and in the younger mice contrast enhancement was significantly elevated in both Sgcd−/− and mdx mice (⁺P< 0.05 versus WT). For the younger mice N as are in Table 1, in the older mice WT N = 9, mdx N = 10, and Sgcd−/− mice N = 15 (as some older mice did not have functional data).