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Table 1 Haemodynamics in young and older mice

From: Heterogeneous abnormalities of in-vivo left ventricular calcium influx and function in mouse models of muscular dystrophy cardiomyopathy

 

YOUNG

OLD

 

WT

Mdx

Sgcd−/−

WT

Mdx

Sgcd−/−

N

11

10

10

7

9

13

Body weight, g

33.3±0.9*

35.8±1.0**

28.8±1.0

40.5±1.2**

37.1±1.1

32.9±0.9

Heart rate, bpm

390±13**

419±14

480±14

384±16**

427±15

483±12

LV mass index, (×10 -3 )

3.03±0.12

3.57±0.13

3.58±0.13

2.80±0.14**

3.56±0.13+

3.86±0.11

EDV index, μl/g

1.97±0.11

1.72±0.11

2.06±0.11

1.93±0.14

1.78±0.12

1.94±0.10

ESV index, μl/g

0.70±0.07

0.68±0.08

0.67±0.08

0.72±0.09

0.74±0.08

0.69±0.07

Stroke volume index, μl/g

1.28±0.06

1.03±0.06**/†

1.38±0.06

1.21±0.07

1.04±0.06†

1.25±0.05

Ejection fraction, %

65±2

61±2††

68±2

63±3

60±2††

65±2

Cardiac index, ml/min/g

0.50±0.03**

0.43±0.03**

0.67±0.03

0.46±0.03#

0.44±0.03**

0.60±0.03

  1. LV: left ventricle; EDV: end-diastolic volume; ESV, end-systolic volume.
  2. *P<0.01 vs older WT.
  3. **P<0.01 vs Sgcd−/− within same age group.
  4. +P<0.05 vs WT within same age group.
  5. #P=0.06 vs Sgcd−/− within same age group.
  6. †P<0.01 ANOVA vs WT and Sgcd−/− both ages combined.
  7. ††P<0.05 ANOVA vs Sgcd−/− both ages combined.
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Journal of Cardiovascular Magnetic Resonance

ISSN: 1532-429X

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