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Table 4 Integrating all nine aortic positions mapped by CMR in the forecasting model, producing interaction terms to describe the nature of the influence

From: Prediction of aortic dilation in Turner syndrome - enhancing the use of serial cardiovascular magnetic resonance

Variable

COARC

Age

BITRI

Antihypertensive treatment

Diastolic ABP

BSA

ERT duration

Aortic sinus

0.06

0.002

0.11

−0.041

−0.0006

0.20

0.0025

(−0.02 - 0.14)

(−0.0002 – 0005)

(0.05 – 0.17)

(−0.067 - -0.015)

(−0.0017 – 0.0005)

(0.02 – 0.38)

(−0.0002 - 0.0052)

Sinotubular junction

−0.002

0.003

0.14

−0.007

−0.0005

0.09

0.0023

(−0.01 – 0.10)

(−0.0002 – 0.005)

(0.07 – 0.21)

(−0.032 – 0.019)

(−0.0016 – 0.0006)

(−0.11 – 0.28)

(−0.0007 - 0.0053)

Mid-ascending aorta

−0.05

0.006

0.18

−0.010

0.0008

0.07

0.00005

(−0.15 – 0.05)

(0.0003 – 0.008)

(0.11 – 0.26)

(−0.034 – 0.014)

(−0.0002 – 0.0018)

(−0.12 – 0.26)

(−0.0030 - 0.0031)

Distal ascending aorta

−0.03

0.004

0.08

0.003

0.0009

0.11

−0.0021

(−0.11 – 0.05)

(0.002 – 0.007)

(0.02 – 0.14)

(−0.018 – 0.023)

(0.00005 – 0.0017)

(−0.05 – 0.27)

(−0.0045 - 0.0004)

Proximal aortic arch

−0.07

0.003

0.08

−0.011

0.0001

0.19

−0.0028

(−0.15 – 0.02)

(0.0007 – 0.006)

(0.02 – 0.14)

(−0.036 – 0.015)

(0.0010 – 0.0013)

(0.01 – 0.36)

(−0.0055 - -0.0002)

Mid aortic arch

−0.07

0.001

−0.003

−0.007

0.0009

0.15

−0.0010

(−0.15 -0.01)

(−0.001 – 0.003)

(−0.06 – 0.05)

(−0.029 – 0.014)

(0.00004 – 0.0018)

(−0.01 – 0.30)

(−0.0034 - 0.0014)

Distal transverse aortic arch

−0.02

0.003

0.02

0.006

0.0017

0.20

−0.0003

(−0.08 – 0.05)

(0.0006 – 0.004)

(−0.03 – 0.07)

(−0.015 – 0.028)

(0.0007 – 0.0026)

(0.06 – 0.34)

(−0.0024 - 0.0018)

Proximal descending

0.22

0.0004

0.05

−0.014

0.0009

0.13

0.0004

(0.14 – 0.29)

(−0.002 – 0.003)

(−0.003 – 0.11)

(−0.034 – 0.006)

(−0.00002 – 0.0017)

(−0.02 – 0.29)

(−0.0020 - 0.0028)

Distal descending aorta

0.14

0.003

0.04

0.011

0.0014

0.21

−0.0005

(0.08 – 0.20)

(0.002 – 0.005)

(−0.002 – 0.09)

(−0.007 – 0.029)

(0.0006 – 0.0022)

(0.08 – 0.34)

(−0.0025 - 0.0014)

P value

<0.0001

<0.0001

0.0004

0.002

0.01

0.6

0.06

  1. Here, we present the interaction terms for parameters that showed an effect on the development in aortic diameter. The β estimates (95% confidence interval) are presented for all aortic positions, and at the bottom of the table p-values are presented. In cases where an interaction term shows an insignificant p-value this indicates that the parameter had a uniform effect on the development of the thoracic aortic diameter. A significant p-value indicates that a parameter influences the development of the thoracic aortic diameter in a variable fashion over time. For example, the presence of a bicuspid aortic valve influenced the entire thoracic aorta, but the effect was most pronounced in the ascending aorta.
  2. Abbreviations: COARC aortic coarctation, BITRI the presence of a bicuspid aortic valve, ABP ambulatory blood pressure, BSA Body surface area, ERT oestrogen replacement.