Figure 3

Correlation of T1 signal intensity change after anthracycline exposure with histopathologic changes in the myocardium. Serial histograms and histopathology of the myocardium before and after receipt of anthracycline. On the top portion of the figure are shown 4-week histograms of the number of pixels (y-axes) and intensities (x-axes) in individual animals after receipt of NS (top left), DOX without an EF drop (top middle), and DOX with an EF drop (top right). Below the histograms are 40× hematoxylin and eosin histopathologic images from the same animals. As shown, mean intensity increased in the animals that had a drop in EF corresponding to vacuolization (arrows, bottom right). Reprinted from Lightfoot, et al. Circ Cardiovasc Imaging 2010[77].