Table 2 Changes in Myocardial signal characteristics after cancer treatment
Study | Cancer therapy | Myocardial signal characterization | How assessed | Subjects (# and type) | Findings |
|---|---|---|---|---|---|
Thompson et al. [74] | Anthracycline chronic toxicity | T1 changes, no T2 changes | Ex vivo spin echo | Rat model | Prolongation of pre-contrast T1. |
Cottin et al. [75] | Anthracycline acute toxicity, 1 week | T1 and T2 changes | Ex vivo inversion recovery for T1, spin echo for T2 | Rat model, n = 23 | Prolongation of pre-contrast T1 and T2. |
Wassmuth et al. [76] | Anthracycline acute toxicity, Day 3 and 28 | T1 changes on Day 3 | Contrast enhanced Spin echo | Humans, n = 79 | Higher signal intensities on T1 weighted imaging. |
Lightfoot et al. [77] | Anthracycline, acute toxicity at 2, 4, 7 and 10 weeks | T1 changes at 2 weeks and 4 weeks | Post-contrast T1 weighted inversion recovery | Rat model, n = 40 | Higher signal intensity than control rats. |
This occurred early after chemotherapy and prior to a drop in the LVEF. | |||||
| Â | Â | Â | Â | Â | This increase in signal intensity was associated with microscopic evidence of cell injury. |