Figure 5

A. Plaque-targeting contrast agents do not accumulate in major organs. A representative plaque-targeting contrast agent and non-targeted control was injected as above and the mouse placed supine for whole body scan. Results are representative of four separate mice. B. C. ATCA does not accumulate in liver or induce toxicity. Mice were treated with or without 1000 μg/100 μl of ATCA via tail vein injection. Two and six days later the serum was used for ALT and AST levels. Data is presented as an average of four (untreated) or four (treated) mice ± SD. No increase in activity was observed between the untreated and treated samples. Activity is measure by Units/L obtained using linear regression from a standard curve.