Figure 3

Dual-gated short axis images in an animal exhibiting infarcted myocardium following 60-min LAD occlusion. Images are shown at baseline, 45-min post-reperfusion, and 1-week post-reperfusion of the occluded artery. The color scale represents the image intensity, normalized by the maximum LV pyruvate signal intensity. Delayed enhancement revealed an enhancing anteroseptal infarct near the apex (arrows). Anteroseptal akinesis was present at the 45-min time point, persisting at 1 week. Apparent PDH flux in the bicarbonate images was reduced at 45 min, remaining suppressed at 1 week. A defect in myocardial lactate signal was observed in the infarct region (arrows), with elevated lactate in the peri-infarct region. (Reproduced with permission Magn Reson Med. 2013 Apr;69(4 ):1063–71).