Figure 2

Troponin I and ECG. A) Blood was drawn for troponin-I (TnI) measurement at three time points: baseline/pre-surgery (Time 0), post-stenosis and post-pacing in model dogs or at the end of CMR examination in sham dogs (Time 1, approximately 2 hours after surgery), and just before euthanasia (Time 2, approximately 3 hours after surgery). While thoracotomy and instrumentation produced minimal TnI elevation in operated sham animals, TnI was significantly higher (though only mildly elevated) in the NSTE-ACS model. B) Representative ECG tracings at baseline and after ischemia (stenosis and pacing) demonstrated premature ventricular contractions but no ST elevation with ischemic conditions in the NSTE-ACS model.