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Table 2 Phosphate Metabolites and Creatine Kinase Flux at Rest and During Plantar Flexion Exercise

From: Skeletal muscle ATP kinetics during exercise in patients with systolic heart failure

 

Healthy (n=11)

SHF (n=14)

PCr/ATP (rest)

4.42 ± 1.67

5.70± 2.0

PCr/ATP (ex)

3.76 ± 1.73¶

4.46± 2.2 ¶

k (s-1)(rest)

0.27 ± 0.04

0.29 ± 0.05

k (s-1)(ex)

0.35 ± 0.11 *

0.35 ± 0.06 *

PCr (µmol/g) (rest)

22.9 ± 8.7

29.4 ± 10.9

PCr (µmol/g)(ex)

18.8 ± 9.7 §

22.2 ± 9.8 §

CK flux (µmol.g-1.s-1)(rest)

6.37 ± 3.15

8.53 ± 2.96

CK flux (µmol.g-1.s-1) (ex)

6.68 ± 4.44

7.57 ± 2.62*

  1. PCr/ATP-phosphocreatine/Adenosine triphosphate ratio; k- CK reaction pseudo first order rate constant; mean±SD, * <0.05 compared to rest; ¶ <0.01 compared to rest, § <0.001 compared to rest