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Figure 2 | Journal of Cardiovascular Magnetic Resonance

Figure 2

From: Acute reperfusion intramyocardial hemorrhage leads to regional chronic iron deposition in the heart

Figure 2

Animal Studies -Representative CMR images (A; T2* in the top row and LGE in the bottom row) acquired from an animal with hemorrhagic myocardial infarction in acute and chronic phases along the long- and short-axis (along the dashed red line in the long-axis images), together with corresponding ex-vivo images are shown (A). In-vivo T2* images (both acute and chronic phases) clearly demonstrate the evidence of signal loss in the LAD territory. Both mean in-vivo T2* (B) and ex-vivo T2* (C) of Hemo+ sections were 40% lower than those of Shams, Remote, and Hemo- in both acute and chronic phases (p<0.001). Mass spectrometric analysis (D) showed that iron content of Hemo+ tissue was 10-fold higher than that of other tissues (p<0.001). Linear regression analysis (E) between log(ex-vivo T2*) and -log([Fe]) showed a strong correlation (R2 = 0.74; p<0.001).

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