Mean percentage edema (A), infarct (B) and salvageable (C) volumes averaged across all the studies are shown at different time points. During ischemia, there was a small but significant amount of edema relative to baseline (p=0.04). Following reperfusion, edema volume increased nearly 5-fold across days 2, 5 and 7 (p<0.001). Percentage edema, infarct and salvageable volumes remained constant across days 2, 5 and 7 (Edema: p=0.78, Infarct: p=0.21, Salvageable: p=0.72). Percentage edema and infarct volumes returned to baseline levels by day 56 (p<0.001 for both cases). Percentage edema volume during ischemia was significantly lower than both post-reperfusion percentage edema and infarct volumes (p<0.001). There was no difference between percentage edema and salvageable volumes computed by T2 maps and T2-STIR images at any time point.