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Table 1 Clinical cases with 4D flow imaging requests and results of analysis.

From: Incorporating time-resolved three-dimensional phase contrast (4D flow) MRI in clinical workflow: initial experiences at a large tertiary care medical center

  

Quantitative results

Subjective 4D Flow Impact Factor (scale: changed clinical impression = 4, quantitative information added = 3, relevant but did not impact case = 2, information not relevant to case = 1)

  

Clinical indication for 4D flow request

Quantitative comparison requested

4D results

2D PC results

Difference (%)

4D flow alone (excludes 2D PC data)

Case including both 2D PC and 4D flow

 

1

Biscuspid aortic valve, flow pattern interest

Regurgitant fraction

16.57%

25%

34%

3

2

 

2

Qp:Qs ratio in patient with VSD

Qsp:Qs ratio

1.22

Not measured

N/A

3

3

 

3

Aortic stenosis, flow pattern interest

Aortic root peak velocity

3.52 m/s

3.8 m/s

7%

2

3

 

4

Biscuspid valve, flow pattern interest

Aortic root peak velocity

2.35 m/s

Note measured

N/A

3

2

Valvular

5

Biscuspid valve, flow pattern interest, aortic regurgitation. Regurgitant jet is very eccentric, limiting 2D assessment

Regurgitant fraction

13.36%

57%

77%

2

3

 

6

Biscuspid aortic valve, flow pattern interest, aortic regurgitation and stenosis assessment

Regurgitant fraction

8.75%

34%

74%

2

3

 

7

Aortic root velocity, 2D PC data underestimated velocity

Aortic root peak velocity

4.08 m/s

3.5 m/s

17%

4

4

 

8

Bicuspid aortic valve, flow pattern interest, aortic regurgitation and stenosis assessment

Regurgitant fraction

4.66%

15%

69%

3

2

Aneurysm

9

Flow pattern interest, aortic dilation

Ascending aorta peak velocity

1.44 m/s

1.3 m/s

11%

3

2

 

10

Aortic stenosis and regurgitation assessment

Regurgitant fraction

38%

55%

31%

3

3

   

Aortic root peak velocity

3.36 m/s

3.8 m/s

12%

  
 

11

Aortic stenosis and regurgitation assessment

Aortic root peak velocity

3.89 m/s

4.0 m/s

5%

4

4

 

12

Flow pattern interest, split flow right-left PA

Peak velocity through pulmonary anastomis

2.32 m/s

1.4 m/s

66%

4

4

   

Peak velocity through pulmonary post-stenosis

2.70 m/s

2.5 m/s

8%

  

Post-surgical

13

Aortic valve assessment

Ascending aorta peak velocity

Could not measure velocity secondary to aliasing artifact

Not measured

N/A

Not available

Not available

 

14

Aortic stenosis and regurgitation assessment

Regurgitant fraction

4.53%

Data limited by artifact

N/A

3

3

   

Aortic root peak velocity

3.11 m/s

Data limited by artifact

N/A

  

Congenital

15

Large pulmonary regurgitant fraction by 2D PC

Pulmonary valve regurgitant fraction

6.41%

21.5%

70%

1

2

 

16

Flow pattern, Qp:Qs

Qp:Qs Ratio

1.08

1

8%

3

3

 

Average

35%

2.93

2.80

 

St dev

28.31%

0.77

0.75