Table 4 Endpoint 2 – death, aborted SCD, appropriate ICD discharge or hospitalization for heart failure
Endpoint 2 | No endpoint | p-value | OR (95% - CI) | |
|---|---|---|---|---|
(n = 26) | (n = 379) | |||
Age [years] | 61.1 (51.2-68.6) | 47 (36–59.5) | <0.001 | |
Gender, female | 9 (34.6) | 168 (44.3) | 0.33 | 0.66 (0.29-1.53) |
Referring physician | ||||
Inpatients | 21 (80.8) | 201 (53.0) | <0.01 | 3.80 (1.40-10.28) |
Outpatients referred by cardiologists | 5 (19.2) | 149 (39.3) | <0.05 | 0.37 (0.14-0.99) |
Outpatients referred by general practitioners | 0 | 29 (7.7) | 0.14 | |
Primary cardiac symptoms leading to CMR | ||||
Reduced LVEF | 15 (57.7) | 67 (17.7) | <0.0001 | 6.35 (2.79-14.44) |
Pericardial effusion | 0 | 6 (1.6) | 0.52 | |
ECG abnormality | 7 (26.9) | 124 (32.7) | 0.54 | 0.76 (0.31-1.85) |
Palpitations | 5 (19.2) | 87 (23) | 0.66 | 0.80 (0.29-2.18) |
Dyspnea | 18 (69.2) | 119 (31.4) | <0.0001 | 4.92 (2.08-11.62) |
Angina/Chest pain | 10 (38.5) | 207 (54.6) | 0.11 | 0.52 (0.23-1.17) |
Abnormal fatigue | 4 (15.4) | 92 (24.3) | 0.30 | 0.57 (0.19-1.68) |
Wall motion abnormality | 0 | 17 (4.5) | 0.27 | |
Ventricular arrythmias/Extrasystoles | 2 (7.7) | 43 (11.3) | 0.57 | 0.65 (0.15-2.85) |
Aborted SCD | 0 | 6 (1.6) | 0.52 | |
Viral Prodrome/history of infectious symptoms | 4 (15.4) | 126 (33.2) | 0.06 | 0.37 (0.05-2.81) |
Atrial fibrillation | 9 (34.6) | 41 (10.8) | <0.001 | 4.35 (1.82-10.39) |
Elevated troponin | 1 (3.8) | 37 (9.8) | 0.32 | 0.37 (0.05-2.81) |
EMB performed | 16 (64) | 62 (17.5) | <0.0001 | 8.40 (3.55-19.88) |
Histological myocarditis in EMB | 10 (62.5) | 43 (70.5) | 0.54 | 0.70 (0.22-2.21) |
CMR imaging parameters | ||||
LVEF [%] | 39 (22.0-59.0) | 63 (57.0-69.0) | <0.0001 | |
LV-EDV [ml] | 181 (126.0-284.0) | 136 (108.0-162.0) | <0.001 | |
LV-ESV [ml] | 123 (52.0-188.0) | 49 (36.0-67.0) | <0.0001 | |
LVEDD [mm] | 58.5 (54.0-65.0) | 50 (45.0-54.0) | <0.0001 | |
Pericardial effusion present | 11 (42.3) | 65 (17.2) | <0.01 | 3.53 (1.55-8.04) |
LGE present | 18 (69.2) | 96 (25.5) | <0.0001 | 6.59 (2.77-15.63) |
Final diagnosis based on CMR | ||||
No cardiac pathology | 1 (3.8) | 224 (59.1) | <0.0001 | 6.59 (2.77-15.63) |
Myocarditis | 17 (65.4) | 99 (26.1) | <0.0001 | 5.34 (2.31-12.37) |
Other cardiac pathology | 8 (30.8) | 55 (14.5) | <0.05 | 2.62 (1.09-6.32) |
Medication | ||||
Betablockers at follow-up | 20 (87.0) | 111 (31.8) | <0.0001 | 14.29 (4.16-49.11) |
ACEI/ARB at follow-up | 20 (87.0) | 87 (24.09) | <0.0001 | 20.08 (5.82-69.20) |