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Table 4 Endpoint 2 – death, aborted SCD, appropriate ICD discharge or hospitalization for heart failure

From: Cardiovascular magnetic resonance risk stratification in patients with clinically suspected myocarditis

  Endpoint 2 No endpoint p-value OR (95% - CI)
  (n = 26) (n = 379)   
Age [years] 61.1 (51.2-68.6) 47 (36–59.5) <0.001  
Gender, female 9 (34.6) 168 (44.3) 0.33 0.66 (0.29-1.53)
Referring physician     
 Inpatients 21 (80.8) 201 (53.0) <0.01 3.80 (1.40-10.28)
 Outpatients referred by cardiologists 5 (19.2) 149 (39.3) <0.05 0.37 (0.14-0.99)
 Outpatients referred by general practitioners 0 29 (7.7) 0.14  
Primary cardiac symptoms leading to CMR     
 Reduced LVEF 15 (57.7) 67 (17.7) <0.0001 6.35 (2.79-14.44)
 Pericardial effusion 0 6 (1.6) 0.52  
 ECG abnormality 7 (26.9) 124 (32.7) 0.54 0.76 (0.31-1.85)
 Palpitations 5 (19.2) 87 (23) 0.66 0.80 (0.29-2.18)
 Dyspnea 18 (69.2) 119 (31.4) <0.0001 4.92 (2.08-11.62)
 Angina/Chest pain 10 (38.5) 207 (54.6) 0.11 0.52 (0.23-1.17)
 Abnormal fatigue 4 (15.4) 92 (24.3) 0.30 0.57 (0.19-1.68)
 Wall motion abnormality 0 17 (4.5) 0.27  
 Ventricular arrythmias/Extrasystoles 2 (7.7) 43 (11.3) 0.57 0.65 (0.15-2.85)
 Aborted SCD 0 6 (1.6) 0.52  
Viral Prodrome/history of infectious symptoms 4 (15.4) 126 (33.2) 0.06 0.37 (0.05-2.81)
Atrial fibrillation 9 (34.6) 41 (10.8) <0.001 4.35 (1.82-10.39)
Elevated troponin 1 (3.8) 37 (9.8) 0.32 0.37 (0.05-2.81)
EMB performed 16 (64) 62 (17.5) <0.0001 8.40 (3.55-19.88)
 Histological myocarditis in EMB 10 (62.5) 43 (70.5) 0.54 0.70 (0.22-2.21)
CMR imaging parameters     
 LVEF [%] 39 (22.0-59.0) 63 (57.0-69.0) <0.0001  
 LV-EDV [ml] 181 (126.0-284.0) 136 (108.0-162.0) <0.001  
 LV-ESV [ml] 123 (52.0-188.0) 49 (36.0-67.0) <0.0001  
 LVEDD [mm] 58.5 (54.0-65.0) 50 (45.0-54.0) <0.0001  
 Pericardial effusion present 11 (42.3) 65 (17.2) <0.01 3.53 (1.55-8.04)
 LGE present 18 (69.2) 96 (25.5) <0.0001 6.59 (2.77-15.63)
Final diagnosis based on CMR     
 No cardiac pathology 1 (3.8) 224 (59.1) <0.0001 6.59 (2.77-15.63)
 Myocarditis 17 (65.4) 99 (26.1) <0.0001 5.34 (2.31-12.37)
 Other cardiac pathology 8 (30.8) 55 (14.5) <0.05 2.62 (1.09-6.32)
Medication     
 Betablockers at follow-up 20 (87.0) 111 (31.8) <0.0001 14.29 (4.16-49.11)
 ACEI/ARB at follow-up 20 (87.0) 87 (24.09) <0.0001 20.08 (5.82-69.20)
  1. Values shown are n (%) or medians (25th -75th percentiles) Abbreviations are the same as in Table 1.