Subclinical myocardial inflammation and diffuse fibrosis are common in systemic sclerosis – a clinical study using myocardial T1-mapping and extracellular volume quantification

Table 4 Tissue characterisation in diffuse SSc vs. limited cutaneous SSc

	Diffuse SSc	Limited SSc	P value
	(n = 10)	(n = 9)	P value
Volume fraction of LGE > 2SD (%)	4 (1-6)	4 (2-5)	0.981
Volume fraction of oedema (T2 STIR SI >1.9, %)	12 (2-17)	14 (0-21)	0.939
Volume fraction of T1 > 990 ms (%)	63 (47-78)	45 925-68)	<0.001
Precontrast T1 (ms)	1011 ± 24	1002 ± 32	0.010
Postcontrast T1 (ms)*	440 ± 44	466 ± 53	0.367
λ	0.63 ± 0.19	0.49 ± 0.22	0.032
ECV (%)	37 ± 4	33 ± 5	0.002

Data are mean ± SD unless otherwise indicated.
*At 20 minutes post gadolinium administration.
λ, Myocardial partition coefficient (Lambda); ECV, Extracellular myocardial volume; LGE, Late gadolinium enhancement; STIR, Short Tau inversion recovery.
For postcontrast T1, λ and ECV, the number of SSc patients included in the analysis is 14 rather than 19.

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