Myocardial perfusion and oxygenation are impaired during stress in severe aortic stenosis and correlate with impaired energetics and subclinical left ventricular dysfunction

Table 2 CMR results in AS patients vs. normal controls

	Aortic stenosis (n = 28)	Normal (n = 15)	P value
BOLD signal intensity change (%)	5.1 ± 8.9	18.2 ± 10.1	0.001
Myocardial perfusion reserve index	1.1 ± 0.3	1.7 ± 0.3	<0.001
Circumferential strain (%)	−16.4 ± 2.7	−21.3 ± 1.9	<0.001
PCr/ATP	1.45 ± 0.21	2.00 ± 0.25	<0.001
LV ejection fraction (%)	74 ± 6	69 ± 4	0.01
LV end-diastolic volume (ml)	142 ± 45	137 ± 33	0.73
LV end-systolic volume (ml)	37 ± 20	42 ± 12	0.43
LV mass index (g/m²)	95 ± 30	56 ± 13	<0.001
Aortic valve area (cm²)	0.84 ± 0.10	4.08 ± 0.73	<0.001
LGE present, n (%)	22 (79)	-	-
LGE volume when positive
Mass (g)	33.2 (17.1-61.8)	-	-
Percentage myocardium (%)	19.7 ± 11.0	-	-

Values are mean ± SD, percentages or median (interquartile range). BOLD, Blood oxygen level dependent; LV, Left ventricular; LGE, Late gadolinium enhancement.

ISSN: 1532-429X