Myocardial perfusion and oxygenation are impaired during stress in severe aortic stenosis and correlate with impaired energetics and subclinical left ventricular dysfunction

Table 3 Cardiac MRI and spectroscopy before and after AVR

	All AS patients (n = 28)	Follow-up AS patients (n = 14)		Controls
	All AS patients (n = 28)	Pre AVR	Post AVR	Controls
BOLD signal intensity change (%)	5.1 ± 8.9	5.1 ± 8.4	15.6 ± 7.0*	18.2 ± 10.1
Myocardial perfusion reserve index	1.1 ± 0.3	1.0 ± 0.4	1.6 ± 0.5*	1.7 ± 0.3
Circumferential strain (%)	−16.4 ± 2.7	−16.3 ± 2.3	−19.4 ± 2.5*	−21.3 ± 1.9
PCr/ATP	1.45 ± 0.21	1.42 ± 0.17	1.86 ± 0.48*	2.00 ± 0.25
Left ventricular mass index (g/m²)	95 ± 30	98 ± 31	69 ± 17†	56 ± 13
Left ventricular ejection fraction (%)	74 ± 7	76 ± 5	74 ± 5^‡	69 ± 4
LGE volume
Mass (g)	33.2 (17.1-61.8)	29.5 (16.7-54.2)	17.7 (15.1-33.9)**	-
Percentage myocardium (%)	19.7 ± 11.0	18.1 ± 10.7	17.2 ± 10.8***	-

Values are mean ± SD or median (interquartile range). ATP indicates adenosine triphosphate; BOLD, Blood oxygen level-dependent; LGE, Late gadolinium enhancement; PCr, Phosphocreatine.
*p < 0.05 vs pre AVR and >0.05 vs controls; †p < 0.05 vs pre AVR and controls; ‡p > 0.05 vs pre AVR and <0.05 vs controls; **p < 0.05 vs pre AVR; ***p > 0.05 vs pre AVR.

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