Figure 5

Left: An axial positive contrast image using Inversion-Recovery with On-resonance water suppression (IRON) of SPIO-labeled stem cells injected in a rabbit thigh demonstrates two injection sites (arrows) as bright hyperintensities. Right: A maximum intensity projection of a 3D T2-prepared MR angiogram shows the region of superficial femoral artery occlusion at 24 hours post-occlusion in a rabbit model of peripheral arterial disease can be registered with the IRON images to determine the location of stem cell injections relative to neovasculature. (Adapted with permission from Kraitchman and Bulte [108]).