Figure 2
From: In vivo characterization of abdominal aortic aneurysms using an elastin specific molecular MR probe
A: The scatter plot shows a significant (p < 0.05) correlation between aneurysmal wall CNR and ICP-MS of collected aortas (n = 15). B: The scatter plot shows a significant (p < 0.05) correlation between aneurysmal wall R1 values and results from ICP-MS of collected aortas. After administration of Gd-DTPA, no significant increase in R1 could be measured compared to the pre-contrast scans. In line with this, ICP-MS demonstrated only a minor accumulation of Gd-DTPA in the aneurysmal wall after 4 weeks (12 ± 5 ppm). C: Typical gadolinium spectra (middle) measured in areas colocalizing with elastic fibers (left). No gadolinium spectra could be acquired in regions not associated with elastic fibers. The specific distribution of gadolinium was mapped in the arterial wall sample (middle). Colocalization of targeted gadolinium with elastic fibers could be found (n = 3). The mapping of sodium as control did not show a specific distribution pattern (right). Values are expressed as mean ± SD.