Multiparametric cardiovascular magnetic resonance assessment of cardiac allograft vasculopathy

Table 1 Associations between patient characteristics, angiography data and CMR data with invasive reference standards of epicardial artery disease (IVUS plaque volumes index; 1) and microvascular disease (IMR; 2).

1. Associations with coronary intravascular ultrasound (IVUS) plaque volume index
Univariable associations	A. Patient characteristics	β	p value
	Time since transplantation	0.49	0.001
	Donor age	0.29	0.058
	B. Angiography data
	Maximum angiographic stenosis	0.33	0.024
	C. CMR data
	Early diastolic SR	-0.38	0.014
	MPR	-0.55	< 0.001
	Infarct LGE	0.35	0.022
Multivariable stepwise regression	A. Including patient characteristics and angiographic data
	Time since transplantation	0.49	0.001
	B. Including patient characteristics and CMR data
	Time since transplantation	0.47	< 0.001
	Early diastolic SR	-0.24	0.049
	MPR	-0.57	< 0.001
2. Associations with index of microcirculatory resistance (IMR)
Univariable associations	A. Patient characteristics
	Donor age	0.39	0.007
	Donor hypertension	0.35	0.016
	B. Angiography data
	Maximum angiographic stenosis	-0.16	0.281
	C. CMR data
	LVEF	-0.36	0.015
	εcc	0.46	0.002
	MPR	-0.55	< 0.001
Multivariable stepwise regression	Donor hypertension	0.29	0.012
	EF	-0.26	0.024
	MPR	-0.60	< 0.001

Only selected data is shown due to table size constraints. 1. On univariable analysis, maximum angiographic stenosis showed a significant association with plaque volume index, however after correcting for time since transplantation, this relationship was no longer significant. Early diastolic strain rate (SR), myocardial perfusion reserve (MPR) and infarct late gadolinium enhancement (LGE) were significantly associated with plaque volume index on univariable analyses, but only MPR and early diastolic SR remained independently associated with plaque volume index on multivariable analysis. 2. Maximum angiographic stenosis was not significantly associated with IMR on univariable analysis. Patient characteristics including donor age and donor hypertension showed significant associations with IMR on univariable analyses, as did CMR parameters such as LV ejection fraction (EF), peak systolic circumferential strain (εcc) and MPR. On multivariable analysis only donor hypertension, EF and MPR remained independently associated with IMR.

ISSN: 1532-429X