Figure 2

A large population of G+LVH- carriers and matched healthy volunteers underwent detailed morphological assessment by CMR evaluating anterior mitral valve leaflet (AMVL) length in the 3-chamber view (method described by Maron et al.), diastolic and systolic wall thicknesses using a 16-segment approach, clefts, trabeculae and other routine CMR parameters. Using conditional logistic regression and leave-one-out cross validation we developed a predictive model for gene carriership in HCM. By CMR and in this descending order of power (I to V), the combined presence of: an elongated AMVL (≥20.5 mm); decreased body surface area-indexed left ventricular end-systolic volume (ESV-i, ≤23.6 mls/m2); increased maximal apical fractal dimension (≥1.279); increased maximal septal systolic wall thickness (SWTs, ≥14.1 mm) and presence of clefts (≥1) predicted gene carriage in this case-control population with a model accuracy of 78%.