Figure 2

(A): In control mice, MPR was 2.0 ± 0.1 and 2.2 ± 0.2 at 18 wks and 24 wks respectively and it reduced to 1.5 ± 0.1 and 1.4 ± 0.2 in the HFD mice (*p < 0.05 vs. age-matched control). (B): LV mass was increased in HFD mice at 18 wks (*p < 0.05 vs. control) and it further increased at 24 wks (*p < 0.05 vs. control, #p < 0.05 vs. HFD at 18 wks). (C): Mid-ventricular end-diastolic wall thickness was increased in HFD mice at 18 and 24 wks after start of diet (*p < 0.05 vs. age-matched control).