From: Titin: a phenotype-genotype descriptive comparison of dilated cardiomyopathy
 | TTN truncation negative (n = 277) | TTN truncation positive (n = 42) | p-value |
---|---|---|---|
CMR data | Â | Â | Â |
LV EDVi (mL/m2) | 136 ± 38 | 140 ± 34.5 | 0.34 |
LV ESVi (mL/m2) | 87.5 ± 39.1 | 96.5 ± 36.7 | 0.07 |
LV SVi (mL/m2) | 48.2 ± 12.9 | 43.4 ± 13.6 | 0.03* |
LV EF (%) | 37.5 ± 12.2 | 32.7 ± 13 | 0.02* |
RV EDVi (mL/m2) | 89.4 ± 24.7 | 90.7 ± 25.5 | 0.71 |
RV ESVi (mL/m2) | 45.2 ± 22.3 | 50.6 ± 24.9 | 0.15 |
RV SVi (mL/m2) | 44.4 ± 12.6 | 40.1 ± 15.6 | 0.09 |
RV EF (%) | 51.6 ± 14.1 | 45.5 ± 15.5 | 0.04* |
LAVi (mL/m2) | 63.8 ± 26.8 | 66.7 ± 25.7 | 0.30 |
LVMi (g/m2) | 95.4 ± 27.6 | 85.5 ± 18.6 | 0.03* |
Lateral WTi (mm/m2) | 3.1 ± 0.7 | 2.8 ± 0.7 | 0.002** |
Septal WTi (mm/m2) | 4.2 ± 0.9 | 3.9 ± 0.8 | 0.02* |
Maximum WTi (mm/m2) | 5.3 ± 1.0 | 4.9 ± 0.9 | 0.01* |
Mid-wall fibrosis present | 94/270 | 13/42 | 0.73 |
Clinical data | Â | Â | Â |
Age at Diagnosis (years) | 53.4 ± 13.3 | 50.4 ± 13.9 | 0.29 |
NYHA status 1/2/3/4 | 116/103/36/1 | 19/16/4/1 | 0.43 |
Sustained VT | 20/97 | 9/14 | 0.001** |
Conduction Disease | 82/227 | 9/37 | 0.19 |
Family history of DCM | 24/218 | 10/38 | 0.018* |