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Table 1 CMR and Clinical Characteristics of DCM patients with and without TTNtv

From: Titin: a phenotype-genotype descriptive comparison of dilated cardiomyopathy

 

TTN truncation negative

(n = 277)

TTN truncation positive

(n = 42)

p-value

CMR data

   

LV EDVi (mL/m2)

136 ± 38

140 ± 34.5

0.34

LV ESVi (mL/m2)

87.5 ± 39.1

96.5 ± 36.7

0.07

LV SVi (mL/m2)

48.2 ± 12.9

43.4 ± 13.6

0.03*

LV EF (%)

37.5 ± 12.2

32.7 ± 13

0.02*

RV EDVi (mL/m2)

89.4 ± 24.7

90.7 ± 25.5

0.71

RV ESVi (mL/m2)

45.2 ± 22.3

50.6 ± 24.9

0.15

RV SVi (mL/m2)

44.4 ± 12.6

40.1 ± 15.6

0.09

RV EF (%)

51.6 ± 14.1

45.5 ± 15.5

0.04*

LAVi (mL/m2)

63.8 ± 26.8

66.7 ± 25.7

0.30

LVMi (g/m2)

95.4 ± 27.6

85.5 ± 18.6

0.03*

Lateral WTi (mm/m2)

3.1 ± 0.7

2.8 ± 0.7

0.002**

Septal WTi (mm/m2)

4.2 ± 0.9

3.9 ± 0.8

0.02*

Maximum WTi (mm/m2)

5.3 ± 1.0

4.9 ± 0.9

0.01*

Mid-wall fibrosis present

94/270

13/42

0.73

Clinical data

   

Age at Diagnosis (years)

53.4 ± 13.3

50.4 ± 13.9

0.29

NYHA status 1/2/3/4

116/103/36/1

19/16/4/1

0.43

Sustained VT

20/97

9/14

0.001**

Conduction Disease

82/227

9/37

0.19

Family history of DCM

24/218

10/38

0.018*

  1. Values are means ± SD for continuous data. TTN, Titin; LV, left ventricular; RV, right ventricular; EDVi/ESVi, end diastolic/systolic volume indexed to body surface area (BSA); SVi, stoke volume indexed to BSA; EF, ejection fraction; LAVi, left atrial volume indexed to BSA; LVMi, LV mass indexed to BSA; WTi, wall thickness indexed to BSA; VT, ventricular tachycardia; NYHA, New York Heart association functional class. *p < 0.05, **p < 0.01