Particle distribution (expressed in particle percentage (pp) as the fraction of total particles released) at four time points in the cardiac cycle at basal, mid and apical level, distributed according to standard 16-segment AHA model (1-16). Mean pp and standard deviation are given in the diagrams, for clustered neighbouring segments. Gray scale coding represents the amount of pp. Statistical significance between neighbouring segments and between patients and controls is expressed as follows: * = p < 0.05, ** = p < 0.01, ***p < 0.001. Segments: 1 Basal anterior, 2 Basal anterior septal, 3 Basal inferior septal, 4 Basal inferior, 5 Basal inferior lateral, 6 Basal anterior lateral, 7 Mid anterior, 8 Mid anterior septal, 9 Mid inferior septal, 10 Mid inferior, 11 Mid inferior lateral, 12 Mid anterior lateral, 13 Apical anterior, 14 Apical septal, 15 Apical inferior 16 Apical lateral.