Figure 1

Representative slice-matched LGE images and contrast-free T1 maps acquired from a canine imaged at 3T (4 months post MI) are shown. Post-processed images delineating the MI territories using Mean+5SD criterion relative to remote myocardium are also shown. Hypointense core of iron deposition within hyperintense MI zone on T1 maps was manually included in the analysis (highlighted light blue pixels on the processed images). AHA 17-segment bulls-eye plots showed excellent correlations between LGE images and T1 maps for measuring infarct volume (IV) and transmurality (IT). Ex-vivo TTC and EMT staining showed extensive replacement fibrosis within MI (top panel), but not in remote myocardium (bottom panel). Strong agreement and correlation were observed between LGE images and T1 maps for measuring chronic IV (Bias = -0.08 ± 0.68% (panel A) and R2 = 0.97 (panel B)) and IT (Bias = 0.45 ± 8.14% (panel C) and R2 = 0.75 (panel D)) at 3T. Area under the curve for detecting chronic MI at 3T using T1 maps was 0.99 (panel E).