Table 1 Demographic, clinical and MRI data of the 4 patients with global heart T2* < 20 ms.
From: Myocardial iron overload in thalassemia major. How early to check?
Parameter | Patient 1 | Patient 2 | Patient 3 | Patient 4 |
|---|---|---|---|---|
Age (yrs) | 9.5 | 6.8 | 8.8 | 7.9 |
Sex | M | F | M | M |
Transfusions starting age (months) | 12 | 7 | 12 | 12 |
Mean Hb pre-transfusion (g/dl) | 9.0 | 9.7 | 9.8 | 9.6 |
Mean serum ferritin in the previous year (ng/ml) | 4500 | 2488 | 2579 | 2359 |
Transfused iron (g) | 32 | 14 | 23 | 27 |
Chelation starting age (months) | 16 | 30 | 24 | 36 |
Chelation treatment at the time of MRI | Deferoxamine | Deferasirox | Deferasirox | Deferoxamine |
Compliance | good | dubious | excellent | excellent |
Previous chelation therapy | None | Deferoxamine | Deferoxamine | -Deferoxamine -Deferasirox |
Global heart T2*/Mid ventricular septum T2* (ms) | 11.2/15 | 13/13 | 16.2/18 | 18.9/24.5 |
MRI CIC (mg/g dry weight) | 2.35 | 1.97 | 1.51 | 1.25 |
N. of pathological segments | 16 | 16 | 12 | 9 |
Pattern of MIO | Homogenous | Homogenous | Heterogeneous | Heterogeneous |
MRI LIC (mg/g dry weight) | 21.4 | 23.3 | 9.6 | 15.1 |
LV EF (%) | 61 | NE | 63 | 59 |
RV EF (%) | 63 | NE | 64 | 56 |