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Table 1 Baseline characteristics and CMR findings

From: Diffuse myocardial fibrosis is subclinical and is associated with impaired myocardial deformation characteristics in systemic lupus erythematosus: a cardiovascular magnetic resonance study

 

Controls

N = 23

SLE

N = 23

P value

Female sex, n (%)

22 (92)

22 (92)

1.00

Age, years

42 ± 9

41 ± 9

0.68

Current smokers, n (%)

1 (4)

3 (13)

0.10

Hypertension, n (%)

0

0

-

Diabetes, n (%)

0

0

-

Hyperlipidaemia, n (%)

1 (4)

0

-

BMI, kg/m2

23 ± 3

28 ± 6

< 0.001

SLEDAI (median, IQR)

N/A

9 (7-14)

-

ESR, mm/hr (median, IQR)

N/A

6 (4-9)

-

CRP, mg/L (median, IQR)

1 (0-1)

3 (2-6)

< 0.001

Hemoglobin, g/L

13 ± 1

12 ± 1

0.37

Duration of SLE, years (median, IRQ)

N/A

9 (6-14)

-

Duration of DMARDs, years (median, IQR)

N/A

7 (4-10)

-

LVEDV indexed to BSA, ml/m2

79 ± 15

78 ± 13

0.91

LVESV indexed to BSA, ml/m2

21 ± 5

20 ± 6

0.43

LVEF, %

74 ± 5

72 ± 5

0.17

LV Mass indexed to BSA, g/m2

49 ± 10

46 ± 11

0.21

LA size, mm

26 ± 4

31 ± 5

< 0.001

Mid SA circumferential strain

-19.3 ± 1.1

-17.0 ± 1.6

< 0.001

Peak diastolic circumferential strain rate (s-1)

119 ± 15

79 ± 26

< 0.001

Presence of LGE (%)

0

5 (22)

-

Volume fraction of LGE > 2SD (%) STIR T2 Ratio

0

2.6 ± 0.2

-

STIR T2 Ratio

1.5 ± 0.1

1.6 ± 0.1

0.06

  1. Continuous data are mean ± SD unless otherwise indicated. BMI, body mass index; CRP, C-reactive protein; DMARD, disease modifying anti-rheumatic drug; ESR, erythrocyte sedimentation rate; IQR, interquartile range; LA, left atrium; LGE, late gadolinium enhancement; LV, left ventricle/ventricular; LVEDV, left ventricular end-diastolic volume; LVEF, left ventricular ejection fraction; LVESV, left ventricular end-systolic volume; SA, short axis; SLEDAI, systemic lupus erythematosus disease activity index; SLE, systemic lupus erythematosus; STIR, short Tau inversion recovery