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Table 1 Genotype Phenotype correlations in HCM [mean (SD) unless stated]

From: Genotype positive hypertrophic cardiomyopathy is associated with myocardial perfusion abnormalities

Variable Genotype POSITIVE Genotype NEGATIVE Significance (NS = not significant)
Number (%) 102 (35%) 186 (65%)  
Male sex (%) 75 (73.5%) 137 (73.7%) NS
BSA (m2) 1.97 (0.22) 1.94 (0.22) NS
Age at CMR (years) 54.6 (12.8) 59.2 (13.4) p = 0.005
Positive family history (%) 22 (21.6%) 35 (18.8%) NS
Length of follow up (months) 37.6 (17.0) 40.8 (20.4) NS
Dead (%) 6 (5.9%) 4 (2.2%) NS
LVEDV (mL) 137.8 (33.6) 134.2 (37.2) NS
LVESV (mL) 34.4 (16.0) 36.2 (19.4) NS
LVSV (mL) 103.4 (25.6) 98.0 (25.0) NS (p = 0.08)
LVEF (%) 75.5 (8.5) 74.1 (8.5) NS
LV Mass (g) 174.8 (54.6) 191.6 (66.2) p = 0.030
LVEDVi (mL/m2) 69.9 (14.5) 69.0 (17.0) NS
LVESVi (mL/m2) 17.4 (7.8) 18.4 (9.2) NS
LV mass index (g/m2) 88.1 (27.6) 98.5 (31.2) p = 0.005
STRESS PERFUSION SCAN POSITIVE 65/79 (82.3%) 87/135 (64.4%) p = 0.015
Max wall thickness (mm) 18.6 (3.7) 19.1 (5.1) NS
Base most affected (%) 68 (66.7%) 103 (55.4%) NS (p = 0.08)
Apex most affected (%) 15 (14.7%) 39 (21.0%) NS
Septum most affected (%) 92 (90%) 154 (82.8%) NS
LGE score (%)    
0 21 (21%) 36 (20%) NS
1 36 (35%) 64 (35%) NS
2 37 (36%) 68 (37%) NS
3 8 (8%) 16 (9%) NS
  1. LGE score: 0=none, 1= minimal, 2= moderate, 3= widespread - as assessed by CMR level 3 accredited observers