Scaled DB AIF (blue) versus SB AIF (red) under adenosine stress. In SB AIF, the first-pass of Gd (first pass: from the beginning of contrast enhancement until just before re-circulation occurs) in (1a) is prone to saturation. Saturation results in lower Gd concentrations (SB is lower than DB AIF at peak and up to the end of first pass). b) Fermi model is fitted to the first pass and c) DP model fitted in all data points. Bland Altman plots assessing bias between DB and SB values (in 8 healthy volunteers) in d) DP model (bias value = 0.19, 95% confidence intervals [-1.32, 0.95]) and e) Fermi model (bias value= -0.93, 95% confidence intervals [-1.47, -0.4]). No significant change was observed in DP whilst Fermi-SB MBF values were significantly higher than Fermi-DB.