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Table 1 Clinical and instrumental correlates in the fibrosis and no-fibrosis group.

From: Myocardial fibrosis by CMR LGE in a large cohrt of pediatric thalassemia major patients

 

Fibrosis

group

(N = 12)

No-fibrosis

group

(N = 64)

P-value

Sex (M/F)

10/2

34/30

0.062

Age (years)

15.4 ± 1.8

13.3 ± 3.5

0.073

Transfusions starting age (years)

1.2 ± 0.9

1.3 ± 0.8

0.691

Chelation starting age (years)

3.1 ± 1.8

3.1 ± 2.3

0.705

HCV antibodies, N (%)

0

3 (4.8%)

0.437

Hb pre-transfusion (g/dl)

9.7 ± 0.3

9.5 ± 0.7

0.757

Ferritin levels (ng/l)

3012 ± 2167

2225 ± 1396

0.226

ALT (u/l)

41.6 ± 12.5

38.6 ± 32.6

0.268

AST (u/l)

46.6 ± 41.2

33.4 ± 25.9

0.207

Global Heart T2* (ms)

20.9 ± 13.9

30.6 ± 9.7

0.022

MRI CIC (mg/g dry weight)

2.0 ± 1.7

0.8 ± 0.6

0.022

Patients with global heart T2* < 20 ms, N (%)

7 (58.3)

12 (18.8)

0.008

N. of seg. with abnormal T2*

9.0 ± 7.0

3.8 ± 5.2

0.030

Left atrial area (cm2)

18.3 ± 3.1

15.9 ± 3.9

0.050

Right atrial area (cm2)

16.9 ± 4.3

14.9 ± 3.5

0.169

Left ventricular end-diastolic volume index (ml/m2)

102.9 ± 23.5

87.0 ± 16.3

0.005

Left ventricular end-systolic volume index (ml/m2)

42.0 ± 12.1

35.1 ± 8.9

0.022

Left ventricular stroke volume index (ml/m2)

60.7 ± 12.4

51.8 ± 10.7

0.012

Left ventricular mass index (g/m2)

65.3 ± 11.4

53.8 ± 11.4

0.003

Left ventricular ejection fraction (%)

59.2 ± 4.4

59.7 ± 5.9

0.368

Right ventricular end-diastolic volume index (ml/m2)

96.9 ± 25.6

81.6 ± 17.1

0.089

Right ventricular end-systolic volume index (ml/m2)

36.9 ± 13.7

32.3 ± 8.3

0.458

Right ventricular stroke volume index (ml/m2)

61.5 ± 11.6

48.9 ± 14.1

0.005

Right ventricular ejection fraction (%)

62.6 ± 4.4

60.2 ± 7.1

0.175