From: Myocardial fibrosis by CMR LGE in a large cohrt of pediatric thalassemia major patients
 | Fibrosis group (N = 12) | No-fibrosis group (N = 64) | P-value |
---|---|---|---|
Sex (M/F) | 10/2 | 34/30 | 0.062 |
Age (years) | 15.4 ± 1.8 | 13.3 ± 3.5 | 0.073 |
Transfusions starting age (years) | 1.2 ± 0.9 | 1.3 ± 0.8 | 0.691 |
Chelation starting age (years) | 3.1 ± 1.8 | 3.1 ± 2.3 | 0.705 |
HCV antibodies, N (%) | 0 | 3 (4.8%) | 0.437 |
Hb pre-transfusion (g/dl) | 9.7 ± 0.3 | 9.5 ± 0.7 | 0.757 |
Ferritin levels (ng/l) | 3012 ± 2167 | 2225 ± 1396 | 0.226 |
ALT (u/l) | 41.6 ± 12.5 | 38.6 ± 32.6 | 0.268 |
AST (u/l) | 46.6 ± 41.2 | 33.4 ± 25.9 | 0.207 |
Global Heart T2* (ms) | 20.9 ± 13.9 | 30.6 ± 9.7 | 0.022 |
MRI CIC (mg/g dry weight) | 2.0 ± 1.7 | 0.8 ± 0.6 | 0.022 |
Patients with global heart T2* < 20 ms, N (%) | 7 (58.3) | 12 (18.8) | 0.008 |
N. of seg. with abnormal T2* | 9.0 ± 7.0 | 3.8 ± 5.2 | 0.030 |
Left atrial area (cm2) | 18.3 ± 3.1 | 15.9 ± 3.9 | 0.050 |
Right atrial area (cm2) | 16.9 ± 4.3 | 14.9 ± 3.5 | 0.169 |
Left ventricular end-diastolic volume index (ml/m2) | 102.9 ± 23.5 | 87.0 ± 16.3 | 0.005 |
Left ventricular end-systolic volume index (ml/m2) | 42.0 ± 12.1 | 35.1 ± 8.9 | 0.022 |
Left ventricular stroke volume index (ml/m2) | 60.7 ± 12.4 | 51.8 ± 10.7 | 0.012 |
Left ventricular mass index (g/m2) | 65.3 ± 11.4 | 53.8 ± 11.4 | 0.003 |
Left ventricular ejection fraction (%) | 59.2 ± 4.4 | 59.7 ± 5.9 | 0.368 |
Right ventricular end-diastolic volume index (ml/m2) | 96.9 ± 25.6 | 81.6 ± 17.1 | 0.089 |
Right ventricular end-systolic volume index (ml/m2) | 36.9 ± 13.7 | 32.3 ± 8.3 | 0.458 |
Right ventricular stroke volume index (ml/m2) | 61.5 ± 11.6 | 48.9 ± 14.1 | 0.005 |
Right ventricular ejection fraction (%) | 62.6 ± 4.4 | 60.2 ± 7.1 | 0.175 |