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Table 1 Clinical and instrumental correlates in the fibrosis and no-fibrosis group.

From: Myocardial fibrosis by CMR LGE in a large cohrt of pediatric thalassemia major patients

  Fibrosis
group
(N = 12)
No-fibrosis
group
(N = 64)
P-value
Sex (M/F) 10/2 34/30 0.062
Age (years) 15.4 ± 1.8 13.3 ± 3.5 0.073
Transfusions starting age (years) 1.2 ± 0.9 1.3 ± 0.8 0.691
Chelation starting age (years) 3.1 ± 1.8 3.1 ± 2.3 0.705
HCV antibodies, N (%) 0 3 (4.8%) 0.437
Hb pre-transfusion (g/dl) 9.7 ± 0.3 9.5 ± 0.7 0.757
Ferritin levels (ng/l) 3012 ± 2167 2225 ± 1396 0.226
ALT (u/l) 41.6 ± 12.5 38.6 ± 32.6 0.268
AST (u/l) 46.6 ± 41.2 33.4 ± 25.9 0.207
Global Heart T2* (ms) 20.9 ± 13.9 30.6 ± 9.7 0.022
MRI CIC (mg/g dry weight) 2.0 ± 1.7 0.8 ± 0.6 0.022
Patients with global heart T2* < 20 ms, N (%) 7 (58.3) 12 (18.8) 0.008
N. of seg. with abnormal T2* 9.0 ± 7.0 3.8 ± 5.2 0.030
Left atrial area (cm2) 18.3 ± 3.1 15.9 ± 3.9 0.050
Right atrial area (cm2) 16.9 ± 4.3 14.9 ± 3.5 0.169
Left ventricular end-diastolic volume index (ml/m2) 102.9 ± 23.5 87.0 ± 16.3 0.005
Left ventricular end-systolic volume index (ml/m2) 42.0 ± 12.1 35.1 ± 8.9 0.022
Left ventricular stroke volume index (ml/m2) 60.7 ± 12.4 51.8 ± 10.7 0.012
Left ventricular mass index (g/m2) 65.3 ± 11.4 53.8 ± 11.4 0.003
Left ventricular ejection fraction (%) 59.2 ± 4.4 59.7 ± 5.9 0.368
Right ventricular end-diastolic volume index (ml/m2) 96.9 ± 25.6 81.6 ± 17.1 0.089
Right ventricular end-systolic volume index (ml/m2) 36.9 ± 13.7 32.3 ± 8.3 0.458
Right ventricular stroke volume index (ml/m2) 61.5 ± 11.6 48.9 ± 14.1 0.005
Right ventricular ejection fraction (%) 62.6 ± 4.4 60.2 ± 7.1 0.175