Figure 1

Representative LGE images and T2*-weighted images (TE=6.9ms) acquired on day 7 (acute) and at 4 months (chronic) post-MI from a canine subjected to permanent ligation of LAD are shown. Arrows point to the site of infarction on LGE images and iron deposition on T2*-weighted images. T2* losses were observed within infarcted territories in both acute and chronic phases of MI indicating iron deposition. Ex-vivo TTC staining showed pale brown discoloration in the core of MI. Microscopic histopathology using Perls staining (scale bars = 200µm) showed significant iron deposition within infarcted territories but not in remote myocardium.