Figure 1

Change in hyperpolarized 13C-bicarbonate-to-[1-13C]lactate ratio following 15 min period of ischemia, compared to baseline. In control experiments, bic-to-lac ratio is near baseline level. After ischemia, the ratio is significantly lower. Occluding higher on LAD results in large area at risk, while occluding lower results in a more variable area at risk and variable metabolic change.