Table 2 CMR and MRS findings

Controls N=12

RA N=16

SLE N=13

P value

LVEDV indexed to BSA, ml/m2

78 ± 15

79 ± 23

74 ± 13

0.54

LVESV indexed to BSA, ml/m2

23 ± 5

23 ± 11

21 ± 6

0.75

LVEF, %

72 ± 4

72 ± 7

72 ± 5

0.96

LV Mass indexed to BSA, g/m2

53 ± 14

55 ± 11

47 ± 7

0.09

LA size, mm

27 ± 5

33 ± 6

29± 4

0.02

Mid SA circumferential strain

-18.7 ± 1.1

-17.5 ± 0.9

-16.5 ± 0.8

<0.001

Peak diastolic circumferential strain rate (s-1)

118 ± 21

88 ± 18

76 ± 24

<0.001

Presence of LGE (%)

0

8 (50)

3 (23)

-

Volume fraction of LGE>2SD (%)

0

3.4 ± 0.4

2.6 ± 0.3

-

Global myocardial T2 SI Ratio

1.5 ± 0.1

1.7 ± 0.3

1.9 ± 0.4

0.03

Volume fraction of oedema by T2 (%)

0

26 (18-39)

20 (13-31)

-

Average myocardial T1, ms

961 ± 12

968 ±25

987 ± 26

0.01

Volume fraction of T1>990ms (%)

3 (1-5)

34 (17-55)

41 (23-61)

<0.001

ECV (%)

26.5 ± 2.7

30.4 ± 3.1

32.2 ± 4.4

<0.001

MPRI

2.0 ± 0.3

1.6 ± 0.2

1.5 ± 0.5

<0.001

PCr/ATP

2.0 ± 0.3

1.5 ± 0.3

1.4 ± 0.3

<0.001

Cardiac lipid content (%)

0.49 ± 0.37

0.46 ± 0.33

0.58 ± 0.27

0.78

Hepatic lipid content (%)

1.70 ± 0.72

1.46 ± 0.58

2.17 ± 1.02

0.64