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Table 1 Comparison of MRI parameters in assessing brain development between normal and CHD newborns.

From: Assessment of MRI parameters for studying brain development in newborns with congenital heart disease

MRI Parameter

Control Mean ± SD

CHD Mean ± SD

P Value

Significant (Y/N)

Brain Volume (mL)

392 ± 57, n=29

362 ± 41, n=18

0.04

Y

MRS:

Centrum Semiovale NAA/Chol Ratio

0.63 ± 0.14, n=28

0.67 ± 0.11, n=18

0.28

N

WM T2 (ms)

269 ± 27, n=6

293 ± 39, n=6

0.04

Y

Fractional Anisotropy (x10 -3 ):

Inferior Frontal WM

Superior Frontal WM

Parietal WM

162 ± 42, n=27

177 ± 39, n=29

182 ± 45, n=29

165 ± 73, n=14

185 ± 66, n=15

183 ± 70, n=15

0.89

0.60

0.98

N

N

N

Apparent Diffusion Coefficient (x10 -6 mm 2 /sec):

Inferior Frontal WM

Superior Frontal WM

Parietal WM

1632 ± 171, n=27

1504 ± 162, n=29

1691 ± 170, n=29

1783 ± 186, n=14

1552 ± 172, n=15

1818 ± 181, n=15

0.01

0.37

0.03

Y

N

Y

  1. MRS - magnetic resonance spectroscopy, WM - white matter.