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Table 1 Control and Patient group characteristics and cardiovascular MR data

From: Characterisation of anthracycline cardiotoxicity in long-term childhood cancer survivors using conventional and novel CMR techniques: probing the pathology

VARIABLE

CONTROL (n = 19)

PATIENTS (n = 30)

p value

Female n (%)

10 (53)

17 (57)

0.86

Current Age (years)

32 (26-39)

32 (23-42)

0.96

Height (cm)

171 ±6.3

169 ±9.2

0.3

Weight (kg)

67 ±8

75 ±21

0.1

NYHA I / II

19 (100) / 0 (0)

28 (93) / 2 (7)

0.44

Systolic BP (mmHg)

120 ±10

123 ±15

0.46

Diastolic BP (mmHg)

73 ±7

75 ±11

0.6

AML n (%)

 

2 (7)

 

ALL n (%)

 

23 (77)

 

Wilms n (%)

 

5 (17)

 

Age at diagnosis (years)

 

4.6 (1-15)

 

Time since chemo (years)

 

25 (16-32)

 

Anth Dose (mg/m2)

 

220 (90-370)

 

Radiotherapy n (%)

 

24 (80)

 

BMT n (%)

 

7 (23)

 

CARDIOVASCULAR MR DATA

   

LVEDV index (ml/m2)

72 ±8

73 ±12

0.92

LVESV index (ml/m2)

25 ±6

30 ±8

*0.05

LV EF (%)

65 ±5

61 ±6

*0.01

LV mass index (g/m2)

60 ±10

58 ±11

0.53

RVEDV index (ml/m2)

76 ±8

69 ±12

0.10

RVESV index (ml/m2)

29 ±6

28 ±14

0.68

RV EF (%)

62 ±4

63 ±5

0.39

MAPSE (cm)

15 ±1.1

13 ±2.6

*0.02

Left Atrial Area (cm2)

20 ±2.3

21 ±3.1

0.47

Native myocardial T1

960 ±37

967 ±37

0.53

Native blood pool T1

1484 ±76

1463±118

0.50

Extracellular volume fraction

 

0.26 ±0.04

 

Focal LGE

 

2 (7)

 
  1. Values expressed mean mean ±SD.
  2. LVEDV = left ventricular end diastolic volume; LVESV = left ventricular end systolic volume; LVEF = left ventricular ejection fraction; RVEDV = right ventricular end diastolic volume; RVESV = right ventricular end systolic volume; RVEF = right ventricular ejection fraction; MAPSE = mitral annular plane systolic excursion; LGE = Late gadolinium enhancement.