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Table 1 Change in primary and secondary endpoints with Ranolazine

From: Effect of late sodium current inhibition on MRI measured diastolic dysfunction and myocardial perfusion reserve in aortic stenosis: a pilot study

Parameter Baseline Week-6 Week-10
MRI parameters
PEDSR (1/s) 0.82 ± 0.130 0.87 ± 0.193 0.81 ± 0.211
MPR 2.69 ± 0.726 2.45 ± 0.559 2.52 ± 0.579
Exercise Parameters
Resting HR (bpm) 74.1 ± 12.0 73.5 ± 13.2 72.0 ± 11.7
Resting SBP (mmHg) 155.9 ± 24.0 148.5 ± 17.9 146.2 ±25.0
Exercise duration (min) 10.88 ± 3.94 11.85 ± 3.39 11.99 ± 3.59
Max HR (bpm) 142.2 ± 11.0 136.5 ± 13.7 140.6 ± 12.7
Max SBP (mmHg) 183.9 ± 20.6 174.5 ± 24.2 179.3 ± 15.1
Resting LVRPP (mmHg.bpm) 14639.7 ± 3228.3 14735.9 ± 3773.6 14512.6 ± 3131.8
Exercise LVRPP (mmHg.bpm) 36342.3 ± 5351.4 34285.9 ± 6902.7 35604.6 ± 4787.5
Echocardiographic parameters
E/A 0.742 ± 0.143 0.765 ± 0.171 0.775 ± 0.159
Septal E/e' 12.57 ± 3.81 13.50 ± 2.95 13.84 ± 3.85
Lateral E/e' 10.93 ± 3.48 10.90 ± 3.37 11.03 ± 2.75
  1. PEDSR: peak early diastolic strain rate, MPR: myocardial perfusion reserve, HR: heart rate, SBP: systolic blood pressure, LVRPP: left ventricular rate pressure product. All p>0.05.