Table 1 Change in primary and secondary endpoints with Ranolazine

Parameter

Baseline

Week-6

Week-10

MRI parameters

PEDSR (1/s)

0.82 ± 0.130

0.87 ± 0.193

0.81 ± 0.211

MPR

2.69 ± 0.726

2.45 ± 0.559

2.52 ± 0.579

Exercise Parameters

Resting HR (bpm)

74.1 ± 12.0

73.5 ± 13.2

72.0 ± 11.7

Resting SBP (mmHg)

155.9 ± 24.0

148.5 ± 17.9

146.2 ±25.0

Exercise duration (min)

10.88 ± 3.94

11.85 ± 3.39

11.99 ± 3.59

Max HR (bpm)

142.2 ± 11.0

136.5 ± 13.7

140.6 ± 12.7

Max SBP (mmHg)

183.9 ± 20.6

174.5 ± 24.2

179.3 ± 15.1

Resting LVRPP (mmHg.bpm)

14639.7 ± 3228.3

14735.9 ± 3773.6

14512.6 ± 3131.8

Exercise LVRPP (mmHg.bpm)

36342.3 ± 5351.4

34285.9 ± 6902.7

35604.6 ± 4787.5

Echocardiographic parameters

E/A

0.742 ± 0.143

0.765 ± 0.171

0.775 ± 0.159

Septal E/e'

12.57 ± 3.81

13.50 ± 2.95

13.84 ± 3.85

Lateral E/e'

10.93 ± 3.48

10.90 ± 3.37

11.03 ± 2.75