Impaired myocardial perfusion is associated with extracellular volume expansion, disease activity and impaired strain and strain rate in systemic sclerosis: a cardiovascular magnetic resonance study

Table 2 Myocardial structure, function and perfusion in SSc patients and controls

	Controls N=17	SSc N=17	P value
LVEDV indexed to BSA, ml/m2	78 ± 17	74 ± 11	0.15
LVESV indexed to BSA, ml/m2	21 ± 5	18 ± 5	0.06
LVEF, %	74 ± 6	73 ± 5	0.36
LV Mass indexed to BSA, g/m2	51 ± 12	51 ± 8	0.89
LA size, mm	28 ± 5	37 ± 6	<0.001
Mid SA circumferential strain	-18.7 ± 1.0	-17.0 ± 1.7	<0.001
Peak diastolic circumferential strain rate (s-1)	114 ± 16	86 ± 24	<0.001
Presence of LGE (%)	0	10 (59)	-
Volume fraction of LGE>2SD (%)	0	2.6 ± 0.3	-
Global myocardial T2 SI Ratio	1.5 ± 0.2	1.7 ± 0.4	0.08
Volume fraction of oedema by T2 (%)	0	18 (7-23)	-
Average myocardial T1, ms	958 ± 22	1, 008 ± 28	<0.001
Volume fraction of T1>990ms (%)	0	59 (43-71)	-
ECV (%)	27.9 ± 2.4	35.4 ± 4.7	<0.001
Rest RPP	7, 989 ± 1, 280	8, 478 ± 1, 829	0.37
Stress RPP	11, 732 ± 1, 789	11, 980 ± 1, 790	0.69
MPRI	2.0 ± 0.4	1.5 ± 0.3	<0.001
Proportion of non-segmental perfusion defects (%)	0	7 (41)	-

Continuous data are mean ± SD unless otherwise indicated.
ECV, extracellular volume; LA, left atrium; LGE, late gadolinium enhancement; LV, left ventricle/ventricular; LVEDV, left ventricular end-diastolic volume; LVEF, left ventricular ejection fraction; LVESV, left ventricular end-systolic volume; MPRI, myocardial perfusion reserve index; RPP, rate pressure product; SA, short axis; SI, signal intensity, SSc, systemic sclerosis

ISSN: 1532-429X