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Table 1 Characteristics of the study cohort and associations with adverse cardiac events and mortality

From: Sarcoidosis: comprehensive CMR evaluation and major adverse cardiac events

  

Major Adverse Cardiac Event

Mortality

Variable

Value

Hazard Ratio

P

Hazard Ratio

P

Age,y*

52 ± 11

1.3(0.9-1.8)

0.168

2.1(1.1-4.4)

0.033

Male

51(55%)

1.4(0.7-3.1)

0.350

0.7(0.15-3.0)

0.601

AV block+

7(8%)

8.8(3.5-21.9)

< 0.001

6.1(1.2-31.4)

0.032

Basal LV thinning+

3(3%)

Not defined

0.989

Not defined

0.995

LV ejection fraction < 50%+

17(18%)

3.1(1.4-6.5)

0.004

6.2(1.4-27.5)

0.018

Ventricular ectopy+

9(10%)

5.0(2.1-11.9)

< 0.001

Not defined

0.995

Right bundle branch block+

16(17%)

3.2(1.4-7.1)

0.005

4.9(1.1-22.3)

0.038

Axis deviation+

19(20%)

2.4(1.4-4.2)

0.002

3.4(1.3-8.9)

0.011

Pathologic Q waves+

7(8%)

4.1(1.7-10.2)

0.002

14.6(3.2-66.9)

< 0.001

LV wall motion abnormality+

11(12%)

3.1(1.3-7.3)

0.011

10.1(2.3-45.2)

0.003

Heart failure

13(14%)

2.5(1.1-5.8)

0.027

4.8(1.1-21.7)

0.040

Coronary artery disease

6(6%)

2.0(0.6-6.5)

0.267

7.8(1.5-40.6)

0.014

Diabetes mellitus

12(13%)

0.8(0.2-2.6)

0.678

1.1(0.1-9.4)

0.912

Hypertension

33(35%)

2.1(1.0-4.3)

0.056

12.2(1.5-101.6)

0.021

Left atrial AP dimension, mm*

35 ± 8

1.0(0.6-1.5)

0.940

3.6(1.7-7.6)

< 0.001

Right atrial 4-chamber dimension, mm*

51 ± 8

0.7(0.4-1.2)

0.193

2.4(1.0-5.3)

0.040

LV end diastolic volume, ml*

163 ± 46

1.1(1.0-1.2)

0.001

1.2(1.1-1.4)

0.007

LV end diastolic volume index, ml/m2*

82 ± 20

1.4(1.2-1.6)

< 0.001

1.4(1.1-1.9)

0.010

LV end systolic volume, ml*

89 ± 40

1.1(1.1-1.2)

< 0.001

1.3(1.1-1.4)

< 0.001

LV ejection fraction,%*

57 ± 11

0.6(0.5-0.8)

0.001

0.5(0.3-0.8)

0.008

LV mass, g*

111 ± 42

1.1(1.0-1.2)

0.056

1.3(1.1-1.5)

< 0.001

RV end diastolic volume, ml*

154 ± 42

1.0(1.0-1.1)

0.318

1.1(0.9-1.3)

0.446

RV end diastolic volume index, ml/m2*

77 ± 16

1.2(1.0-1.5)

0.074

1.3(0.8-2.1)

0.393

RV end systolic volume, ml*

69 ± 28

1.1(1.0-1.2)

0.236

1.2(1.0-1.4)

0.100

RV ejection fraction, %*

56 ± 7

0.8(0.5-1.4)

0.474

1.0(0.3-3.4)

0.950

Presence of LGE+

15(16%)

2.2(0.9-5.2)

0.072

0.9(0.1-7.8)

0.956

Number of segments with LGE

1 ± 3

1.1(1.0-1.3)

0.042

1.2(0.9-1.4)

0.204

Steroid therapy

37(40%)

0.5(0.2-1.1)

0.087

2.7(0.5-14.9)

0.248

  1. *Hazard ratio shown for a 10 unit change.
  2. +Included in the Japanese Ministry of Health guideline for the diagnosis of cardiac sarcoidosis, revised 2006.
  3. Abbreviations as in the text.