A) Phosphocreatine (PCr) concentration is depleted with rapid resistive extremity exercise and returns to baseline levels within a recovery period (τ), which is a well-established biomarker of mitochondrial oxidative function. A representative recovery curve is shown. B) Comparison of PCr recovery times demonstrates sequentially poorer mitochondrial oxidative capacity in control subjects, non-diabetic and diabetic patients. C) A representative quantitative fat image acquired through the leg illustrates the measurement of intramuscular lipid. D) Comparison of results indicates sequentially higher skeletal muscle fat content in control subjects, non-diabetic and diabetic patients.