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Table 1 Demographic, biochemical and multiparametric MRI results.

From: Cardiac and hepatic phenotype of diabetes in the presence and the absence of obesity - mechanistic role of ectopic/visceral adiposity

 

Controls N=12

Lean T2DM patients N=15

Obese T2DM patients N=27

P value

Age, y

50 ± 10

56 ± 9

56 ± 8

0.16

BMI, kg/m2

23 ± 3

23 ± 2

33 ± 3*

<0.001

Male,%

58

60

41

0.41

Diabetes Duration, years

...

6.1 ± 4.7

6.6 ± 6.5

0.78

Glycated hemoglobin, %

...

7.4 ± 0.9

7.7 ± 1.4

0.22

ALT, IU/L

22 ± 9

30 ± 22

36 ± 17

0.12

Multiparametric Liver MRI

cT1,ms

753 ± 45

821 ± 67

924 ± 116*

<0.001

Hepatic triglyceride content, % (Lipid/water ratio)

3.6 ± 3.5

7.7 ± 4.6

14.8 ± 8.4*

<0.001

CMR and Cardiac MRS Findings

LV end-diastolic volume, ml

145 ± 40

124 ± 33

126 ± 25

0.15

LV mass, g

98 ± 26

123 ± 33†

119 ± 28†

0.01

LV mass to LV end-diastolic volume, g/ml

0.63 ± 0.13

0.95 ± 0.26

0.89 ± 0.20

<0.001

Peak systolic circumferential strain, negative (-),%

18.1 ± 2.1

16.5 ± 2.6†

13.4 ± 3.6*

<0.001

Peak circumferential diastolic strain rate, s-1

74 ± 20

68 ± 19*

56 ± 26†

0.006

Mycocardial PCr/ATP ratio

2.08 ± 0.40

1.75 ± 0.29*

1.64 ± 0.32*

0.003

Mycocardial triglyceride, %(Lipid/water ratio)

0.48 ± 0.28

1.14 ± 0.66†

1.22 ± 0.91†

0.02

  1. Values are mean ± standard deviations or percentages. T2DM indicates type 2 diabetes mellitus; CMR, cardiac magnetic resonancel cT1, corrected T1; ms, milliseconds; PCr, Phs phocreatine *p < 0.05 vs controls and lean T2Dm †p < 0.05 vs controls